The using of a piglets as a model for evaluating the dipyrone hematological effects
نویسندگان
چکیده
BACKGROUND Dipyrone (MET, metamizole) is a non-steroidal anti-inflammatory drug commonly used both in human and in veterinary medicine. After oral administration, is broken down rapidly to metabolites which largely retain the activity of the parent drug. Its metabolites have analgesic, antipyretic and anti-inflammatory effects. RESULTS The subjects were eight healthy male Large White post-suckling piglets, weighing between 5.0 to 7.4 kg, of ages 35 ± 10 days. The animals were administered MET (100 mg/kg) by an intramuscular (I.M.) injection. The study calculated the value of several hemorheological parameters. Significant impact of MET treatment (p < 0.05) was proven in case: activated partial thromboplastin time; ratio of activated partial thromboplastin time; hemoglobin; hematocrit; mean corpuscular hemoglobin; mean corpuscular volume; red blood cells volume; white blood cells volume; prothrombin time index. CONCLUSIONS In summation, our observations suggest that a piglet model is useful for studying the impact of MET on hemorheological parameters.
منابع مشابه
Evaluating Effects of Ziziphora Tenuior on Digestibility, Hematological, Serum Biochemical Indices, Fecal Bacteria and Nematode Population of Ewes
Extended Abstract Introduction and Objective: Ziziphora one of aromatic and medicinal plants that have a wide distribution in Iran. This study was to investigate the effects of supplemented different levels of Ziziphora tenuior to diet on digestibility, hematological, serum biochemical indices, fecal bacteria and nematode population of Dalagh ewes. Material and Methods: Twelve matured Dalagh...
متن کاملEvaluating the Effects of Enrofloxacin on Angiogenesis Using the Chick Embryo Chorioallantoic Membrane Model
Objective- Because little information was available in the literature about the angiogenic property of enrofloxacin, this investigation was undertaken to evaluate this aspect using an in vivomodel. Design- Experimental study. Animals- Twenty fertile chicken eggs (Ross 308) with the average egg-weight of 55 ± 0.4 g were rand...
متن کاملEvaluating the effect of using turmeric (Curcuma longa) on growth performance and hematological parameters of the ornamental fish, Green Terror (Andinocara rivulatus)
Shape and size of the body, color's beauty and its healthy condition are among the main factors for selling of ornamental fish in the market. Researchers have tended to use herbal additives as growth promoter and immune stimulator agents. The aim of this study is to evaluate the effects of turmeric powder (Curcuma longa) as a dietary supplement for the ornamental fish Green Terror (Andinocara r...
متن کاملEffects of Low Dose Gamma Ray on Some Hematological Parameters in Adult Rats
Introduction: The study aimed to find the low dose effect gamma ray on some hematological parameters in male albino rats obtained from the Mosul University, IRAQ, and also studied the radioprotective effect of black seed oil on the hematological parameters. Material and Methods: The system is made of 241Am as gamma source .The...
متن کاملApplication of hurdle model with random effects for evaluating the balance improvement in stroke patients
Background: Stroke is a prevalent cause of disability in adults. The fall is the most common balance and motor impairments, which affects the quality of life in stroke patients. This study aims to employ random effects hurdle model for evaluating the balance improvement in stroke patients under the occupational therapy. Methods: In this longitudinal study with repeated measurement during on...
متن کامل